Phenyltetrahydroisoquinoline–Pyridinaldoxime Conjugates as Efficient Uncharged Reactivators for the Dephosphylation of Inhibited Human Acetylcholinesterase-Reference-Cited by-同舟云学术

Phenyltetrahydroisoquinoline–Pyridinaldoxime Conjugates as Efficient Uncharged Reactivators for the Dephosphylation of Inhibited Human Acetylcholinesterase

Published:2012-11-26 Issue:23 Volume:55 Page:10791-10795
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mercey Guillaume¹²³,Renou Julien¹²³,Verdelet Tristan¹²³,Kliachyna Maria⁴,Baati Rachid⁴,Gillon Emilie⁵,Arboléas Mélanie⁵,Loiodice Mélanie⁵,Nachon Florian⁵,Jean Ludovic¹²³,Renard Pierre-Yves¹²³

Affiliation:

1. Université de Rouen, COBRA CNRS UMR 6014 and FR 3038, IRCOF, 1 Rue Tesnière, 76821 Mont St. Aignan Cedex, France

2. INSA de Rouen, Avenue de l’Université, 76800 St. Etienne du Rouvray, France

3. CNRS Délégation Normandie, 14 Rue Alfred Kastler, 14052 Caen Cedex, France

4. Université de Strasbourg, Faculté de Pharmacie, CNRS UMR 7199, BP 24, 67401 Illkirch, France

5. Cellule Enzymologie, Département de Toxicologie, Institut de Recherche Biomédicale des Armées, 24, Avenue des Maquis du Grésivaudan, BP 87, 38702 La Tronche, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm3015519

Reference35 articles.

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2. Organophosphates⧸Nerve Agent Poisoning: Mechanism of Action, Diagnosis, Prophylaxis, And Treatment

3. Effects of low-level exposure to sarin and cyclosarin during the 1991 Gulf War on brain function and brain structure in US veterans

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