1. Departments of Biopharmaceutics, Pharmacology, and Medicinal Chemistry, Shenyang Pharmaceutical University, Shenyang, 110016, China, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, 113-0033, Japan, Division of Hematology/Oncology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029-6547, and Institute of Pharmacology Toxicology, Academy of Military Medical Sciences, Beijing, 100850, China