Fused Piperidines as a Novel Class of Potent and Orally Available Transient Receptor Potential Melastatin Type 8 (TRPM8) Antagonists-Reference-Cited by-同舟云学术

Fused Piperidines as a Novel Class of Potent and Orally Available Transient Receptor Potential Melastatin Type 8 (TRPM8) Antagonists

Published:2012-02-13 Issue:4 Volume:55 Page:1593-1611
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tamayo Nuria A.¹,Bo Yunxin¹,Gore Vijay¹,Ma Vu¹,Nishimura Nobuko¹,Tang Phi¹,Deng Hong¹,Klionsky Lana¹,Lehto Sonya G.¹,Wang Weiya¹,Youngblood Brad¹,Chen Jiyun¹,Correll Tiffany L.¹,Bartberger Michael D.¹,Gavva Narender R.¹,Norman Mark H.¹

Affiliation:

1. Departments of †Chemistry Research and Discovery, §Neuroscience, ‡Analytical Research and Development, and ∥Pharmacokinetics and Drug Metabolism, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm2013634

Reference40 articles.

1. TRP channels as cellular sensors

2. Structural Biology of TRP Channels

3. TRPM8 mRNA Is Expressed in a Subset of Cold-Responsive Trigeminal Neurons From Rat

4. A TRP Channel that Senses Cold Stimuli and Menthol

5. Inhibition of TRPM8 by Icilin Distinct from Desensitization Induced by Menthol and Menthol Derivatives

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