A Scalable Process for the Synthesis of 2-Methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine Monohydrate and 4-[(Biphenyl-2-ylcarbonyl)amino]benzoic Acid: Two New Key Intermediates for the Synthesis of the AVP Antagonist Conivaptan Hydrochloride-Reference-Cited by-同舟云学术

A Scalable Process for the Synthesis of 2-Methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine Monohydrate and 4-[(Biphenyl-2-ylcarbonyl)amino]benzoic Acid: Two New Key Intermediates for the Synthesis of the AVP Antagonist Conivaptan Hydrochloride

Published:2005-08-23 Issue:5 Volume:9 Page:593-598
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Tsunoda Takashi¹,Yamazaki Atsuki¹,Mase Toshiyasu¹,Sakamoto Shuichi¹

Affiliation:

1. Process Chemistry Labs., Astellas Pharma Inc., 160-2, Akahama, Takahagi-shi, Ibaraki 318-0001, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op050061n

Reference13 articles.

1. Pharmacological profile of YM087, a novel nonpeptide dual vasopressin V1A and V2 receptor antagonist, in dogs

2. Practical Synthesis of N-{4-[(2-Methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin- 6(1H)-yl)carbonyl]phenyl}biphenyl-2-carboxamide Monohydrochloride: an Arginine Vasopressin Antagonist

3. 444. Azabenzocycloheptenones. Part II. Dieckmann cyclisation of arylamino-esters

4. Brominations with Pyridine Hydrobromide Perbromide

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