1. Dipartimento di Scienze Farmaceutiche, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy, Department of Molecular and Integrative Physiology, University of Illinois, 407 S. Goodwin Avenue, Urbana, Illinois 61801, and Department of Chemistry, University of Illinois, 600 S. Mathews Avenue, Urbana, Illinois 61801