Dopamine D4 Ligands and Models of Receptor Activation: 2-(4-Pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and Related Heteroarylmethylarylpiperazines Exhibit a Substituent Effect Responsible for Additional Efficacy Tuning-Reference-Cited by-同舟云学术

Dopamine D4 Ligands and Models of Receptor Activation: 2-(4-Pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and Related Heteroarylmethylarylpiperazines Exhibit a Substituent Effect Responsible for Additional Efficacy Tuning

Published:2004-03-23 Issue:9 Volume:47 Page:2348-2355
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Stewart Andrew O.¹,Cowart Marlon D.¹,Moreland Robert B.¹,Latshaw Steve P.¹,Matulenko Mark A.¹,Bhatia Pramila A.¹,Wang Xueqing¹,Daanen Jerome F.¹,Nelson Sherry L.¹,Terranova Marc A.¹,Namovic Marian T.¹,Donnelly-Roberts Diana L.¹,Miller Loan N.¹,Nakane Masaki¹,Sullivan James P.¹,Brioni Jorge D.¹

Affiliation:

1. Department R4ND, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-6115

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0305669

Reference62 articles.

1. G-Protein Coupled Receptors: Models, Mutagenesis, and Drug Design

2. GPCRs come of age in San Diego

3. Inverse, protean, and ligand‐selective agonism: matters of receptor conformation

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