Sequential C–H Arylation and Enantioselective Hydrogenation Enables Ideal Asymmetric Entry to the Indenopiperidine Core of an 11β-HSD-1 Inhibitor-Reference-Cited by-同舟云学术

Sequential C–H Arylation and Enantioselective Hydrogenation Enables Ideal Asymmetric Entry to the Indenopiperidine Core of an 11β-HSD-1 Inhibitor

Published:2016-11-17 Issue:47 Volume:138 Page:15473-15481
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Wei Xudong¹,Qu Bo¹,Zeng Xingzhong¹,Savoie Jolaine¹,Fandrick Keith R.¹,Desrosiers Jean-Nicolas¹,Tcyrulnikov Sergei²,Marsini Maurice A.¹,Buono Frederic G.¹,Li Zhibin¹,Yang Bing-Shiou¹,Tang Wenjun¹,Haddad Nizar¹,Gutierrez Osvaldo²,Wang Jun¹,Lee Heewon¹,Ma Shengli¹,Campbell Scot¹,Lorenz Jon C.¹,Eckhardt Matthias³,Himmelsbach Frank³,Peters Stefan³,Patel Nitinchandra D.¹,Tan Zhulin¹,Yee Nathan K.¹,Song Jinhua J.¹,Roschangar Frank¹,Kozlowski Marisa C.²,Senanayake Chris H.¹

Affiliation:

1. Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877, United States

2. Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States

3. Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397 Biberach/Riss, Germany

Funder

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.6b09764

Reference73 articles.

1. World Health Organization. Global status report on noncommunicable diseases 2014;World Health Organization:Geneva, Switzerland, 2014.

2. bCenters for Disease Control and Prevention. National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States, 2014;U.S. Department of Health and Human Services:Atlanta, GA, 2014.

3. Eckhardt, M.; Peters, S.; Mar, H.; Himmelsbach, F.Patent WO 2011/057054 A1, 2011.

4. Scalable Total Synthesis and Biological Evaluation of Haouamine A and Its Atropisomer

Cited by 53 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. P-Stereogenic Phosphorus Ligands in Asymmetric Catalysis;Chemical Reviews;2024-07-02

2. General and Scalable Synthesis of 2-Aryl and 2-Alkyl Pyrimidines via an Electronically Tuned S_NAr Approach;Organic Letters;2024-05-24

3. Broad Survey of Selectivity in the Heterogeneous Hydrogenation of Heterocycles;The Journal of Organic Chemistry;2024-01-19

4. Colloidal ruthenium catalysts for selective quinaldine hydrogenation: Ligand and solvent effects;Chemistry – A European Journal;2024-01-17

5. Bulky P-stereogenic ligands. A success story in asymmetric catalysis;Coordination Chemistry Reviews;2023-08