Synthesis of mesoporous silicate molecular sieves by the aerosol-assisted method for loading and release of drug

Abstract

The mesoporous silicate molecular sieves were synthesized with polyether F127 as the template by the aerosol-assisted method for loading and release of ibuprofen (IBU). The synthesized samples were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction and N 2 adsorption–desorption isotherms. The drug IBU was applied as a model drug to investigate the drug release behaviour by ultraviolet spectrophotometry measurements. The investigation results demonstrate that mesoporous silicate molecular sieves by the aerosol-assisted method are spherical with a core–shell structure. As the drug carrier, it has good structural stability and can achieve drug controlled release which is expected. It exhibits safety to a certain degree. Therefore, the aerosol-assisted synthesis method provides a new idea for the synthesis of sustained-release drug carriers.