1. Department of Biochemistry and Biophysics, University of PennsylvaniaPhiladelphia, PA 19104-6059, USA
2. Manchester Interdisciplinary Biocentre, University of Manchester131 Princess Street, Manchester M1 7ND, UK
3. School of Chemical Engineering and Analytical Science, University of Manchester131 Princess Street, Manchester M1 7ND, UK
4. Faculty of Life Sciences, University of Manchester131 Princess Street, Manchester M1 7ND, UK