Affiliation:
1. Biotechnology Laboratory, University of British Columbia, Room 237,Wesbrook Building, 6174 University Boulevard,Vancouver, British Columbia, V6T 1Z3, Canada
Abstract
Salmonellosis (diseases caused bySalmonellaspecies) have several clinical manifestations, ranging from gastroenteritis (food poisoning) to typhoid (enteric) fever and bacteraemia.Salmonellaspecies (especiallySalmonella typhimurium) also represent organisms that can be readily used to investigate the complex interplay that occurs between a pathogen and its host, bothin vitroand in vivo. The ease with whichS. typhimuriumcan be cultivated and genetically manipulated, in combination with the availability of tissue culture models and animal models, has madeS. typhimuriuma desirable organism for such studies. In this review, we focus onSalmonellainteractions with its host cells, both in tissue culture (in vitro) and in relevant animal models (in vivo), and compare results obtained using these different models. The recent advent of sophisticated imaging and molecular genetic tools has facilitated studying the events that occur in disease, thereby confirming tissue culture results, yet identifying new questions that need to be addressed in relevant disease settings.
Subject
General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology
Cited by
88 articles.
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