Supercritical carbon dioxide: putting the fizz into biomaterials

Author:

Barry John J.A12,Silva Marta M.C.G12,Popov Vladimir K3,Shakesheff Kevin M1,Howdle Steven M2

Affiliation:

1. Tissue Engineering Group, School of Pharmacy, The University of NottinghamUniversity Park, Nottingham NG7 2RD, UK

2. School of Chemistry, The University of NottinghamUniversity Park, Nottingham NG7 2RD, UK

3. Institute of Laser and Information Technologies, Russian Academy of SciencesPionerskaya 2, Troitsk, Moscow Region 142092, Russia

Abstract

This paper describes recent progress made in the use of high pressure or supercritical fluids to process polymers into three-dimensional tissue engineering scaffolds. Three current examples are highlighted: foaming of acrylates for use in cartilage tissue engineering; plasticization and encapsulation of bioactive species into biodegradable polyesters for bone tissue engineering; and a novel laser sintering process used to fabricate three-dimensional biodegradable polyester structures from particles prepared via a supercritical route.

Publisher

The Royal Society

Subject

General Physics and Astronomy,General Engineering,General Mathematics

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