Abstract
Ceramide is an endogenous lipid molecule generated by hydrolysis of membrane sphingomyelin, in response to cellular stimulation by hormones and cytokines. Ceramide appears to have a role in mediating biological responses in a wide variety of cell types. These responses are generally considered antiproliferative, but endpoints are varied and include differentiation, growth inhibition, senescence and apoptotic cell death. Mechanisms for ceramide action involve regulation of protein phosphorylation via stimulation of a serine/threonine protein phosphatase, a proline-directed kinase and possibly other direct and/or indirect targets.
Subject
General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology
Reference35 articles.
1. Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide. J. biol;Ballou L. R.;Chem.,1992
2. Ceramide-mediated biology. biol;Bielawska A.;Chem.,1992
3. Selectivity of ceramide-mediated biology. J. biol;Bielawska A.;Chem.,1993
4. Cloning and characterization of LCB1, a Saccharomyces gene required for biosynthesis of the long-chain base component of sphingolipids
5. Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest.
Cited by
46 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献