Evaluation the anti-proliferative effect of Pistacia atlantica gum extract as a natural compound on the human cervical cancer cell line (TC1 cells)

Author:

Abstract

Background: This survey was aimed at investigating the anti-proliferative impact of Pistacia atlantica gum extract as a natural compound on cervical cancer associated with papillomavirus. Methods: Aqueous extract of dried and milled Pistacia atlantica gum extract was assembled and evaluated by GC-MS. The MTT test was utilized for evaluating the antiprolifrative impacts of Pistacia atlantica gum extract (100, 200, and 400mg/ml). Furthermore, the estimation of perniciousness was possible via the survival ability of cells, and ROS production, apoptosis, and levels of caspase-8, and -9 proteins were specified. Results:A considerable (p<0.01) reduction in proliferation indicator (70.138 ± 8.464), a considerable (p <0.01) increase in apoptosis (71.66% ± 4.041) of TC1 cells, a noticeable (p <0.03) increase in ROS formation (15.69 ± 0.799) and a noticeable (p <0.01) increase in LDH release (17.83 ± 0.772) were evident in the adjacency of TC1 cells by a Pistacia atlantica gum extract (400 mg/ml) witha dose-dependent behavior in compared to control group. Moreover, a considerable (p < 0.05) increase was recorded in the activities of caspase-8 (0.097 ± 0.007) and caspase-9 (0.065 ± 0.004). Conclusion: The growth of TC1 cells could be suppressed, and cell apoptosis via could be evoked by the aqueous extract of Pistacia atlantica gum through extrinsic death-receptor-dependent apoptosis as well as intrinsic mitochondrial-dependent apoptosis. Therefore, the aqueous extract of Pistacia atlantica gum may be used as a natural compound for the treatment of disorders of papillomavirus.

Publisher

DoNotEdit

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3