A New Photoluminescent 3D Supramolecular Zn(II) Complex and Its Therapeutic Effect on Diabetic Ocular Complications-Reference-Cited by-同舟云学术

A New Photoluminescent 3D Supramolecular Zn(II) Complex and Its Therapeutic Effect on Diabetic Ocular Complications

Published:2021-10-01 Issue:10 Volume:13 Page:1931-1936
ISSN:1947-2935
Container-title:Science of Advanced Materials
language:en
Short-container-title:sci adv mater

Author:

Cao Chanyuan¹,Chen Jinyan²,Luo Yongjun³,Deng Zhen¹,Zhu Shuang⁴,Wang Xin⁵,Zhao Wei-Wei⁵

Affiliation:

1. Department of Ophthalmology, First People’s Hospital of Linping District, Hangzhou, Zhejiang, 311199, China

2. Department of Endocrinology, Pu’er People’ Hospital, Pu’er, Yunan, 665000, China

3. R&D, Focused Photonics (Hangzhou) Inc., Hangzhou, Zhejiang, 310051, China

4. Department of Endocrinology, Taizhou First People’s Hospital, Taizhou, Zhejiang, 318028, China

5. Department of Medicine, Xuzhou Medical University, Huai’an, Jiangsu, 223002, China

Abstract

The hydrothermal reaction among Zn(NO3)2 · 6H2O, 1,3,5-benzenetricarboxylic acid (H3BTC), and 7-hydroxy-5-methyl-1,3,4-triazaindolizine (Hmtpo) synthesized a fresh complex of [Zn(HBTC)(HATAZ)(H2O)2]n · 2n(H2O) · n(Hmtpo) (1, HATAZ is 3-amino-1,2,4-triazole). This supramolecular framework showed intense luminescence emission at RT. For treating diabetic ocular complications, the preventive and therapeutic effects of the compound on diabetic ocular complications were analyzed, and the detailed mechanism was investigated. ELISA was conducted to examine the inflammatory cytokines generated through the fundus arterial endothelial cells. Furthermore, RT-PCR was carried out to determine the oxidative stress level in the fundus arterial endothelial cells.

Publisher

American Scientific Publishers

Subject

General Materials Science

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