Size- and Morphology-Controlled Preparation of Surface-Modified Water-Dispersible Fullerene Nanoparticles for Bioapplications

Author:

Oguma Hidetoshi1,Seitoku Eri1,Mutoh Mami1,Yoshizawa Saori1,Nakanishi Ko1,Bando Yosuke1,Era Yuko1,Kiba Takayuki2,Saikaew Pipop3,Tamai Miho1,Akasaka Tsukasa1,Nakamura Mariko4,Kusaka Teruo1,Yoshida Yasuhiro1,Sato Yoshiaki1,Sano Hidehiko1,Abe Shigeaki1,Alireza Valanezhad5,Watanabe Ikuya5,Inoue Satoshi1,Takada Tomoya6

Affiliation:

1. Faculty of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan

2. Department of Materials Science and Engineering, Kitami Institute of Technology, Kitami 080-8507, Japan

3. Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand

4. School of Health Science, Kyushu University of Health and Welfare, Nobeoka 882-8508, Japan

5. Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto 1-7-1, Nagasaki 852-8102, Japan

6. Department of Applied Chemistry and Bioscience, Chitose Institute of Science and Technology, Chitose 066-8655, Japan

Abstract

In this study, we investigated water-dispersible surface modification for size- and shape-controlled fullerene nanoparticles (C60P) based on a condensation reaction with di-amino alkane. This modification provided for water dispersibility of C60P and the capability for secondary modification as well. The resultant C60P particles have several useful physical properties: water-dispersibility for ease of injection; fluorescence for detection and quantification; and a characteristic morphology to assist identification. These properties will widely extend the applications of these particles, especially into the biological fields of bioimaging and drug delivery.

Publisher

American Scientific Publishers

Subject

Condensed Matter Physics,General Materials Science,Biomedical Engineering,General Chemistry,Bioengineering

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