PM2.5 is a risk factor of hypertension: A study on regression model for risk factors of hypertension

Abstract

Objective: In this prospective observational research, we aimed to explore the association among PM2.5 concentration, hypertension and clinical factors in Taiyuan at different times by regression analysis. Methods: This prospective observational research enrolled 95 cases with hypertension and 98 healthy individuals who went to our hospital during March 2017 to September 2018. PM2.5 concentrations data were collected from the national urban air quality report released by China environmental monitoring station. Age, BMI and sex of all subjects were recorded. DBP, SBP, cytokines and VEGF, ANG-2, white blood cells (WBC), fibrinogen (Fib), fasting plasma glucose (FPG) and lipid metabolic factors levels of all subjects were collected in the first week of each month during November 2018 to October 2019. Results: The PM2.5 concentration of winter spring (WS) group were remarkably increased than that in summary autumn (SA) group. Meanwhile, the SBP and DBP of patients with hypertension in WS group were markedly elevated than that in SA group. Similar results were showed in the healthy volunteers. The TNF-α, IL-6, IL-1β, VEGF, Fib and TC levels of patients with hypertension in WS group were dramatically enhanced than the SA group. Positive correlation was observed between PM2.5 concentration and IL-6, VEGF, FPG, IL-1β and TC. PM2.5 concentration and FPG, TC, TG, IL-6, VEGF were the risk factors for hypertension. Conclusion: This study showed that SBP and DBP increased when PM2.5 concentration raised. PM2.5 concentration was related to the clinical factors of patients with hypertension.