Therapeutic effect and mechanism of silver nanowires on radiation pneumonitis by inhibiting the excessive inflammatory response of epithelial cells

Abstract

Three new silver nanowire (Ag NW) samples with different diameters and lengths were synthesized by the polyol synthesis method. The diameter and length of Ag NWs1–3with high yield and purity were regulated by changing the amount of Fe3+ions at 140 °C, producing new synthesized methods in designing and obtaining Ag NWs with desired size and morphology. Samples Ag NWs1–3were fully characterized by scanning electron microscopy and powder X-ray diffraction. ELISA was further conducted to measure the release of TNF-αand TGF-β1 from epithelial cells after Ag NWs1–3treatment. Then, real time RT-PCR was performed, and the activation of AMPK signaling pathway in epithelial cells was evaluated.