Repair Effect and Mechanism of Electrospinning Nanocomposite Material with Gelatin-Bletilla Striata Gum/Salvia Miltiorrhiza on Orthopedic Refractory Wounds

Abstract

For improving the wound healing probability of patients, this work discussed the application value and mechanism of nano-electrospinning (NES) composites combined with gelatin-Bletilla striata gum (BSG)/Salvia miltiorrhiza (SM) in the repair of orthopedic refractory wounds (ORWs). 40 patients with ORWs were included and randomly rolled into a control group (Ctrl group, treated with only NES composite) and an observation group (Obs group, NES+ gelatin-BSG/SM composite), with 20 cases in each. The expression levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and transforming growth factor beta 1 (TGF-β1) in the Obs group were higher than those in the Ctrl group (P<0.05). NES composite combined with gelatin-BSG/SM could promote the formation of tissues and blood vessels in ORWs by upregulate VEGF, b-FGF, and TGF-β1. Therefore, it was more conducive to the healing and repair of ORWs.