PDA-PEG-Ce6-Mn Multifunctional Nanoparticles for Magnetic Resonance Images-Guided Photo-Dynamic/Photo-Thermal Therapy

Abstract

One of the most common brain cancer type is gliomas. Although traditional multi-modal therapy has made some progress, overall poor prognosis and low long-run rate of patient’s survival still persist. Due to its selective, noninvasive and repetitive nature, photo-dynamic/photo-thermal therapy (PDT/PTT) is considered to enhance therapeutic effect of glioma. We report a new type of polydopamine (PDA) nanoparticle with targeting ability and excellent PDT/PTT synergistic effect. The Mn2+ chelated nanocomposite material exhibited a favorable contrast T1-weighted magnetic resonance images (MRI). In the U251 tumor-bearing mouse model, near-infrared (NIR) imaging and MRI-guided PDT/PTT achieved significant synergistic therapeutic effects compared to their single treatment methods. Conclusively, PDA-PEG-Ce6-Mn nanoparticle demonstrated high potential in the diagnosis and treatment of glioma.