The Analgesic Effect of Dexmedetomidine Loaded with Nano-Hydrogel as a Novel Nano-Drug Delivery System for Thoracic Paravertebral Block After Thoracic Surgery

Abstract

Objective: To understand the effect of dexmedetomidine (Dex) thoracic paravertebral block combined with an injectable nano-drug delivery system in postoperative analgesia after thoracic surgery, an injectable nano-drug delivery system. Methods: Dex-loaded nano-hydrogel was first prepared in this study and its characteristics and drug release performance in vitro was investigated. Then, it was applied to the postoperative analgesia of 140 patients undergoing thoracic surgery. Results: It was found that the loading efficiency reached the highest when the ratio of Dex to injectable nano-hydrogel was 1:1; and at pH = 7.5, the cumulative release of 95.4%. The visual analogue scale (VAS) score and cumulative effective pressure times of analgesia pump in the observation group were lower than those of the control group. The sleep time per day and satisfaction of analgesia within 48 h in patients from the observation group were higher than those of the control group. The proportion of patients with remedial analgesia within 48 hours, and the proportion of patients with nausea and vomiting were significantly lower in patients treated with Dex-loaded with nano-hydrogel. Conclusion: Injectable nano-drug delivery system had good drug release and combination of Dex thoracic paravertebral block and nano-drug delivery system could significantly relieve pain after thoracic surgery and improve patients’ sleep quality.