Enhancement of Antioxidant/Anti-Inflammatory Activity, and Acceleration of Wound Healing Through the Combination of Ginger Extract and NAC: A Promising Approach

Abstract

In recent years, there has been significant development and application of bioactive materials with antioxidant and anti-inflammatory properties in skin regenerative medicine. In this study, we utilized sodium hyaluronate (HA), which has good biological activity and compatibility, as a carrier for material mixing. Ginger extract (GE), a natural biologically active compound, was combined with N-Acetyl-L-cysteine (NAC) for the treatment of skin wounds. GE was extracted from fresh ginger juice through freeze-drying, which exhibit pharmacological effects such as antioxidant, anti-inflammatory, and antibacterial properties. Additionally, NAC possesses notable pharmacological activities, particularly as an antioxidant and anti-inflammatory agent. By harnessing the natural advantages of GE in combination with NAC for wound healing, remarkable results were observed in terms of antioxidant efficacy, anti-inflammatory effects, promotion of granulation tissue and wound repair processes. These outcomes surpassed those achieved by using the individual components alone. These experimental findings underscore the potential of combining plant-based medicines and chemical drugs. This approach strengthens the synergistic effects of drug efficacy, reduces the use of and side effects associated with chemical drugs, and holds significant research and development potential. Moreover, it promotes the wider adoption and application of traditional Chinese medicine technology.