Clinical Characteristics and Endometrial Lesions of Postmenopausal Patients with Abnormal Uterine Bleeding

Abstract

This study delves into factors linked to abnormal uterine bleeding and endometrial issues during perimenopause. Analyzing clinical data from 333 perimenopausal patients with abnormal uterine bleeding, we identified key variables influencing endometrial lesions. Of these cases, 26.1% exhibited normal endometrium, while 63.1% had benign lesions (including polyps, leiomyomas, and hyperplasias), and 10.5% presented with endometrial cancer. Single-factor analysis revealed correlations between factors like age, BMI, parity, hypertension history, IUD usage, family cancer history, bleeding duration, endometrial characteristics, and tumor markers, and distinct endometrial changes (P <0.05). Multivariate analysis emphasized the significance of age groups (40–45, 45–50, 50–55 years) and endometrial thickness on benign and malignant lesions (P <0.05). As perimenopausal abnormal uterine bleeding rises, early detection of these factors and the establishment of an effective diagnostic and treatment framework will greatly enhance the well-being of perimenopausal women.