Treatment activity of hydrogels loaded with cobalt metal–organic frameworks of urinastatin on sepsis acute lung injury

Abstract

The reaction of Co(II) salt with 5-tert-butylbenzene-1,3-dicarboxylic acid (5-tert-H2IPA) and N,N′-bis(3-pyridyl) terephthalamide (L) in a mixed solvent of H2O and CH3CN affords a new coordination polymer [Co(L)0.5(5-tert-IPA)]n (1). Based on the slow release of the drug, hydrogels loaded with Co(II) metal–organic frameworks of urinastatin were prepared. SEM images showed that the hydrogels had a highly porous morphology. Furthermore, the treatment activity of the hydrogels on sepsis acute lung injury was assessed. ELISA detection results showed that the hydrogels significantly reduced the levels of the IL-6 and UL-18 released into the alveolar lavage fluid. The relative expression of the lncRNA NANCI in lung epithelial cells was also inhibited by the hydrogels in a dose-dependent manner.