Daptomycin Cross-Linked Chitosan Nanoparticles Serve as an Antibacterial Drug Delivery System

Abstract

This report was aimed to investigate smart chitosan-daptomycin nanoparticles (CTS-DAP NPs) prepared by a simple ionic gelation method and to document their bacteriostatic activity towards infections. The particle size of optimal CTS-DAP NPs was 146.3 ± 0.09 nm, with narrow polydispersity index and zeta potential of 24.87 ± 1.06 mV. The drug loading efficiency of CTS-DAP NPs was 60.8%, and their in vitro drug release behavior exhibited that DAP could be released sustainedly. Zone of inhibition (ZOI) test, which was used to determine the activity of CTS-DAP NPs against S. aureus, showed the inhibitory zone diameter increased from 11.7 to 15.06 mm along with increased DAP dose from 1.25 to 10 μg loaded in CTS-DAP NPs. Taken together, the CTS-DAP NPs may provide a reliable approach to inhibit bacterial infections.