Preparation of Chitosan-Based Fiber Reticulated Medical Dressing and Its Application in Wound Care

Abstract

With the continuous development of medical dressings, patients start to focus on how to take care of wounds caused by different reasons. Therefore, there is a need for medical dressings that can stop the bleeding and promote the healing of wounds with excellent biological properties. This study produced seven different dressing samples by combining chitosan fiber and hydroentanglement technique. The different dressings were characterized and analyzed for biological properties. At the same time, 60 New Zealand rabbits were selected for wound care experiments. Respectively, the wounds were constructed and were treated with sample 1 and sample 3, which were selected as experimental materials from the prepared dressing samples. Besides, the polyacrylate (SAP) and common gauze were taken as the control materials. Then, different dressings were used to cover the wounds of rabbits. Three days later, the dressings were changed every few days to observe the wounds. At the same time, the wound area and wound healing scores of the sample 1 group, sample 3 group, and SAP group were counted at 7 days, 14 days and 21 days after the operations. During the experiment, the chitosan fiber-based fiber web dressing showed excellent hygroscopicity and rigidity. For the comparison of biological properties, different samples all had excellent cell compatibility and antibacterial properties. Meanwhile, the antibacterial properties of sample 1 and sample 3 were all above 90%. For the wound care experiment, the adsorbent rate of sample 1 dressing was the fastest in the first 8 min, reaching 70% of the maximum liquid absorption. For the comparison of the wound recovery area and wound healing scores, compared with SAP and common gauze, the medical dressings based on composite chitosan fiber-hydroentanglement technique had better wound recovery performance. This has proved that the medical dressings proposed in this study have better wound care performances.