A rare case of pulmonary lymphomatoid granulomatosis complicated with venous thrombosis

Senem Maral; Murat Albayrak; Hacer Berna Afacan Öztürk; Funda Incekara; Abdulkerim Yıldız; Pınar Comert; Aynur Abayrak; Merih Reis Aras; Sadi Kaya

doi:10.36141/svdld.v38i4.10140

A rare case of pulmonary lymphomatoid granulomatosis complicated with venous thrombosis

Authors

Senem Maral a:1:{s:5:"en_US";s:40:"Dıskapı Research and Training Hospital";}
Murat Albayrak Ankara Dıskapı Yıldırım Beyazıt Research and Training Hospital, Department of Hematology
Hacer Berna Afacan Öztürk Ankara Dıskapı Yıldırım Beyazıt Research and Training Hospital, Department of Hematology
Funda Incekara Ankara Ataturk Chest Disease and Chest Surgery Research and Training Hospital, Department of Chest Disease
Abdulkerim Yıldız Ankara Dıskapı Yıldırım Beyazıt Research and Training Hospital, Department of Hematology
Pınar Comert Ankara Dıskapı Yıldırım Beyazıt Research and Training Hospital, Department of Hematology
Aynur Abayrak Ankara City Training Hospital, Department of Pathology
Merih Reis Aras Ankara Dıskapı Yıldırım Beyazıt Research and Training Hospital, Department of Hematology
Sadi Kaya Ankara Ataturk Chest Disease and Chest Surgery Research and Training Hospital, Department of Chest Dise

Keywords:

Lymphomatoid granulomatosis, Venous thromboembolic events, Rituximab

Abstract

Lymphomatoid granulomatosis (LG) is Epstein-Barr virus associated, a rare aggressive B cell lymphoproliferative disease. The most common sites of involvement are lungs, skin, kidneys, liver and central nervous system. The clinical presentation of pulmonary LG can mimic infectious diseases, malignancies or vasculitis. While treatment approach of low grade disease is watch and wait, patients with advanced stage require aggressive treatment with chemotherapy. Patients with hematological malignancy as well as solid tumors are at increased risk of venous thromboembolic events (VTE). We reported here in a case of pulmonary LG who was complicated with VTE during treatment with chemo-immunotherapy After 4 cycles of R-CHOP, she achieved complete remission for LG and was followed up without relapse for 2 years. She was anticoagulated with Low-Molecular-Weight Heparin (LMWH) during chemotherapy period, and the thrombus improved over the next several weeks. While on this paper written patient was pregnant with 10 weeks.

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