Zinc(II) Complex with 2-Hydroxy-5-ethylphenylphosponic Acid: Synthesis, Structure, Toxicity, and Accumulation in HeLa Cells-Reference-Cited by-同舟云学术

Zinc(II) Complex with 2-Hydroxy-5-ethylphenylphosponic Acid: Synthesis, Structure, Toxicity, and Accumulation in HeLa Cells

Published:2023-08-01 Issue:8 Volume:68 Page:1066-1076
ISSN:0044-457X
Container-title:Журнал неорганической химии
language:
Short-container-title:Žurnal neorganičeskoj himii

Author:

Ivanova I. S.¹,Tsebrikova G. S.²,Ilyukhin A. B.¹,Solov’ev V. P.²,Lapshina M. A.³,Rogacheva Yu. I.³,Pyatova E. N.¹,Baulin V. E.³,Tsivadze A. Yu.²

Affiliation:

1. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

2. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences

3. Institute of Physiologically Active Substances, Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences

Abstract

A complex of zinc(II) with 2-hydroxy-5-ethylphenylphosphonic acid (H3L) of the composition [Zn(H2L)2(Н2О)2][Zn(HL)(Н2О)]·H2O (I) was synthesized, the structure of which was established based on data of X-ray diffraction and elemental analysis, quantum chemical calculations, as well as IR and electron absorption spectroscopies. The stability constants of H3L acid complexes with zinc(II) perchlorate in water were determined by potentiometric titration. The cytotoxic properties of H3L acid and complex I were studied for the first time on HeLa cells (human cervical adenocarcinoma). The results on the accumulation of complex I in HeLa cells were obtained by laser confocal microscopy.

Publisher

The Russian Academy of Sciences

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