Affiliation:
1. Institute of Biology, FRC Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Abstract
We studied the cytogenetic effects in the bone marrow cells of root voles (Alexandromys (Microtus) oeconomus Pall.), which lived in areas contaminated with uranium and radium, as a result of the operation of radium mining (radium site) and the storage of its waste (uranium-radium site) (Komi Republic). The level and nature of mutational effects in voles from radioactively contaminated areas indicates the persistence of an increased frequency of chromosome aberrations and the appearance of individuals with an altered karyotype, which indicates genetic instability. When determining the nature of the dynamics of the mutation process in the studied populations, a high frequency of cells with micronuclei was noted in voles from the radium area, with the exception of the phase of population decline. In experiments with the use of provocative factors of chemical (urethane) and radiation (acute γ-irradiation) nature, an increase in the stability of bone marrow cells of animals living in conditions of increased background radiation has been shown.
Publisher
The Russian Academy of Sciences
Reference43 articles.
1. Taira W., Hiyama A., Nohara C. et al. Ingestional and transgenerational effects of the Fukushima nuclear accident on the pale grass blue butterfly // J. Radiat. Res. 2015. V. 56. № 1. P. i2–i18. https://doi.org/10.1093/jrr/rrv068
2. Hancock S., Vo N.T.K., Byun S.H. et al. Effects of historic radiation dose on the frequency of sex-linked recessive lethals in Drosophila populations following the Chernobyl nuclear accident // Environ. Res. 2019. V. 172. P. 333–337. https://doi.org/10.1016/j.envres.2019.02.014
3. Cannon G., Kiang J.G. A review of the impact on the ecosystem after ionizing irradiation: wildlife population // Int. J. Radiat. Biol. 2020. P. 1–9. https://doi.org/10.1080/09553002.2020.1793021
4. Мазурик В.К., Михайлов В.Ф. Радиационно-индуцированная нестабильность генома: феномен, молекулярные механизмы, патогенное значение // Радиац. биология. Радиоэкология. 2001. Т. 41. № 3. С. 272–289. [Mazurik V.K., Mikhajlov V.F. Radiatio-ninduced genome instability: the phenomenon, mole-cular mechanisms, pathogenetical significance // Radiats. biology. Radioekology. 2001. V. 41. № 3. Р. 272–289. (In Russ.)]
5. Кичигин А.И., Таскаев А.И. “Водный промысел”: история производства радия в Республике Коми (1931–1956 гг.) // Вопр. истории естествознания и техники. 2004. № 4. С. 3–30. [Kichigin A.I., Taskaev A.I. “Vodnyy promysel”: istoriya proizvodstva radiya v Respublike Komi (1931–1956 gg.) // Voprosy istorii estestvoznaniya i tekhniki. 2004. V. 4. P. 3–30. (In Russ.)]