Neuronal exosomes as a new signaling system

Abstract

Every year more and more works are devoted to the study of neuronal exosomes. The potential of exosomes as diagnostic markers for neurodegenerative diseases has been significantly explored., and similar marker search patterns have been adopted for the study of psychiatric pathologies. The fundamentals of exosome biogenesis in different cell types have been elucidated., the physiological significance of exosomes is being actively studied., and many aspects of signaling with their participation are being elucidated. At the same time., data have been accumulated pointing to the role of exosomal signaling as an important element of interneuronal communication. Do we have enough evidence to call exosomes a new non-canonical neurotransmitter in the brain? This discussion work is devoted to answering this question., in which the author presents to the scientific community the concept of the possible role of brain exosomes as a signaling system.