Affiliation:
1. N.N. Semenov Federal Research Center for Chemical Physics
2. N.E. Bauman Moscow State Technical University
3. Stavropol State Medical University
Abstract
A therapeutic effect of high-dose nitric oxide gas inhalation (more than 1000 ppm) on patients with post-COVID syndrome, diabetes or AIDS is shown. It has been proposed that nitrosonium cations (NO+), derivatives of nitric oxide gas, the emergence of which in the blood or organ tissues of patients is related to disproportion reaction of NO molecules, forming a co-ordinate bond with the Fe2+ion, carried by transferrin or entered into the labile (free) iron pool may act as a therapeutic agent. It is quite probable that treatment of HIV infection (as well as the earlier revealed effect of NO gas on the patients with COVID-19) could be provided by the effects of S-nitrosylation of NO+ cations on thiol groups of viral proteases and host proteins. A beneficial effect of NO+ cations which emerged in the reaction of NO gas molecules in patients with post-COVID syndrome or diabetes can be also associated with an inhibitory effect of these cations on the thiol-containig proteins that are involved in apoptosis.
Publisher
The Russian Academy of Sciences
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