Affiliation:
1. Kazan Federal University
Abstract
Clonidine hydrochloride, an agonist of the α2-adrenergic receptor, was tested for its effect on the parameters of the electrical activity of the atrial myocardium induced by pacing. In the experimental rat cardiomyocyte pacing model, clonidine hydrochloride caused a decrease (approximately 50% and 90%) in action potential duration in adult rats. Treatment of one- and three-week-old rats with this agonist led to an increase (around 50% and 90%) in action potential duration
Publisher
The Russian Academy of Sciences
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