The Relationship Between Obstructive Coronary Artery Disease and Serum 25-OH Vitamin D, Fetuin-A, Matrix Gla Protein, and ADMA Levels

Abstract

In this study, the relationship between the markers of 25OH-vitamin D, Matrix Gla Protein (MGP), Fetuin-A, Asymmetric Dimethyl Arginine (ADMA), which are suggested to play a role in the etiology of atherosclerosis, and coronary artery disease was investigated. For this purpose, a total of 80 patients, including 40 patients with normal coronary artery and 40 patients with 70% or more stenosis in at least one coronary artery, who underwent coronary angiography with a preliminary diagnosis of coronary artery disease, were included in the study. While blood MGP levels were observed to be significantly higher in the coronary artery disease group compared to the control group (2082.79±329.75 pg/ml and 1853.42±285.82 pg/ml, p=0.001, respectively), Fetuin-A levels in the control group group was significantly lower than the coronary artery disease group (60.54±28.61 ng/ml and 78.61±20.45 ng/ml, respectively, p=0.002). Although 25OH-vitamin D levels were observed at low levels in 85% of the patients in both groups, no statistically significant difference was found between the two groups (20.27±12.65 ng/ml and 20.64±7.32 ng/ml, respectively). ml, p=0.875). When blood ADMA levels were examined, no statistically significant difference was observed between the groups (group 1; 0.099±0.053 umol/l and group 2; 0.089±0.051 umol/l, p>0.05). As a result; While no significant relationship was found between 25OH-vitamin D and ADMA values ​​and coronary artery disease, it was observed that MGP and Fetuin-A could be markers for occlusive coronary artery disease. In our study, it was observed that MGP and Fetuin-A biomarkers were guiding in the diagnosis of occlusive coronary artery disease. In the light of these findings, new studies with a similar background and larger populations are needed to evaluate the use of MGP and Fetuin-A levels in the diagnosis of coronary artery disease.