Inherited frailty and longevity

Author:

Vaupel James W.1

Affiliation:

1. Center for Population Analysis and Policy, Humphrey Institute of Public Affairs, University of Minnesota, Minneapolis, Minnesota 55455

Abstract

Abstract The lifespansof parents and children appearonly weakly related,even though parents affect their children’s longevity through both genetic and environmental influences. These influences can be summarizedas a correlation betweenparents’and children’s frailty. It isshownthat even ifchildren perfectly inherit their frailty from their parents, parents’ life spans explain little of the variance in children’s life spans, because the variance in life expectancies among people with different frailties is small compared with the variancein life spansamongpeopleat the same leveloffrailty. Byinterpreting frailty as a relative risk in a proportional-hazard model, longevity as a duration or waiting time, and inheritance as an invariance in relative risk over time, one can extend this result to repeatable events involving fertility, migration, marriage, unemployment, and so forth.

Publisher

Duke University Press

Subject

Demography

Reference36 articles.

1. Thefamilial component in longevity—A study of offspring of nonagenarians, III: Intrafamilial studies;Abbott;American Journal of Medical Genetics,1978

2. A theory of mortality based on actuarial, biological and medical considerations;Beard,1963

3. Data for the problem of evolution in man, II: A first study of the inheritance of longevity and the selective death-rate in man;Beeton;Proceedings of the Royal Society of London,1899

4. On the inheritance of the duration of life, and on the intensity of natural selection in man;Beeton;Biometrika,1901

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