Lymphadenopathy and granulomas: benignancy of malignancy and differential diagnosis with endobronchial ultrasound-transbronchial needle biopsy 19G needle fine-needle aspiration biopsy

Author:

Zarogoulidis Paul12ORCID,Hatzibougias Dimitris3,Tsakiridis Kosmas4,Matthaios Dimitris5,Hohenforst-Schmidt Wolfgang6ORCID,Huang Haidong7,Bai Chong7,Tryfon Stavros8,Saroglou Maria8,Zaric Bojan9,Boujkovinas Ioannis10,Karapantzou Chrisanthi11

Affiliation:

1. 3rd University Surgery Department, AHEPA University General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece

2. Pulmonary Department, ‘Bioclinic’ Private Clinic, Thessaloniki, Greece

3. Microdiagnostics Private Pathology Laboratory, Thessaloniki, Greece

4. Thoracic Surgery Department, ‘Interbalkan’ European Medical Center, Thessaloniki, Greece

5. Oncology Department, General Hospital of Rhodos, Rhodos, Greece

6. Department of Cardiology/Pulmonology/Intensive Care/Nephrology, Sana Clinic Group Franken, ‘Hof’ Clinics, University of Erlangen, Hof, Germany

7. Department of Respiratory & Critical Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, PR China

8. Pulmonary Department (NHS), ‘G Papanikolaou’ General Hospital, Thessaloniki, Greece

9. Faculty of Medicine, University of Novi Sad, Institute for Pulmonary Diseases of Vojvodina, Novi Sad, Serbia

10. Oncology Department, ‘Bioclinic’ Private Clinic, Thessaloniki, Greece

11. Ear, Nose & Throat (ENT) Department, Ludwig-Maximilians University of Munich, Munich, Germany

Abstract

Endobronchial ultrasound (EBUS) is a very useful tool for the diagnosis of lymphadenopathy of the mediastinum. Nowadays, EBUS can substitute video-assisted thoracic surgery when a 19G needle is used. Several studies have provided data for efficient diagnosis not only for lung cancer, but for also sarcoidosis, tuberculosis and lymphoma. We present five cases of EBUS-transbronchial needle biopsy 19G needle used for the diagnosis of mediastinum lymphadenopathy. We present not only the pathological diagnosis, but also the steps for the differential clinical and pathological differential diagnosis for sarcoidosis, tuberculosis, cancer metastasis, respiratory infection and lymphoma.

Publisher

Future Medicine Ltd

Subject

Pulmonary and Respiratory Medicine,Oncology

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