Analyses of tumor microenvironment in patients with advanced renal cell carcinoma receiving immunotherapy (Meet-URO 18 study)

Author:

Catalano Fabio1ORCID,Brunelli Matteo2,Signori Alessio3ORCID,Rescigno Pasquale45ORCID,Buti Sebastiano67ORCID,Galli Luca8,Spada Massimiliano9,Masini Cristina10,Galuppini Francesca11,Vellone Valerio Gaetano1213,Gaggero Gabriele12,Maruzzo Marco14ORCID,Merler Sara15,Vignani Francesca16,Cavo Alessia17,Bimbatti Davide14,Milella Michele15,Dei Tos Angelo Paolo11,Sbaraglia Marta11,Murianni Veronica1,Damassi Alessandra1,Cremante Malvina1,Maffezzoli Michele6ORCID,Llaja Obispo Miguel Angel1,Banna Giuseppe Luigi1819ORCID,Fornarini Giuseppe1ORCID,Rebuzzi Sara Elena2021ORCID

Affiliation:

1. Medical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy

2. Pathology Unit, Department of Diagnostics & Public Health, University & Hospital Trust of Verona, 37124, Verona, Italy

3. Department of Health Sciences (DISSAL), Section of Biostatistics, University of Genoa, 16132, Genoa, Italy

4. Candiolo Cancer Institute, FPO-IRCCS, 10060, Candiolo, Italy

5. Translational & Clinical Research Institute, Centre for Cancer, Newcastle University, Newcastle upon Tyne,  NE1 7RU, UK

6. Department of Medicine and Surgery, University of Parma, 43126, Parma, Italy

7. Medical Oncology Unit, University Hospital of Parma, 43126, Parma, Italy

8. Medical Oncology Unit 2, Azienda Ospedaliera Universitaria Pisana,    56126, Pisa, Italy

9. UOC Oncologia Medica, Istituto Fondazione G. Giglio, 90015,  Cefalù, Italy

10. Medical Oncology Unit, Clinical Cancer Centre, AUSL-IRCCS di Reggio Emilia, 42122, Reggio Emilia, Italy

11. Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, 35128, Padua, Italy

12. Pathology Unit, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy

13. Department of Integrated Surgical & Diagnostic Sciences (DISC), University of Genoa, 16132, Genoa, Italy

14. Oncology Unit 1, Istituto Oncologico Veneto IOV–IRCCS, 35128, Padua, Italy

15. Section of Innovation Biomedicine–Oncology Area, Department of Engineering for Innovation Medicine, University of Verona & Verona University & Hospital Trust, Verona, 37134, Italy

16. Division of Medical Oncology, Ordine Mauriziano Hospital, 10128, Turin, Italy

17. Oncology Unit, Villa Scassi Hospital, 16149, Genoa, Italy

18. Department of Oncology, Portsmouth Hospitals University NHS Trust, Portsmouth, PO6 3LY, UK

19. School of Pharmacy & Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2UP, UK

20. Medical Oncology Unit, Ospedale San Paolo, 17100, Savona, Italy

21. Department of Internal Medicine & Medical Specialties (Di.M.I.), University of Genoa, 16132, Genoa, Italy

Funder

LILT–Lega Italiana per la Lotta ai Tumori

Publisher

Informa UK Limited

Reference34 articles.

1. Update on combined immunotherapy for the treatment of advanced renal cell carcinoma

2. Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

3. AIOM. Linee Guida Tumori del Rene. Edizione 2021. Available from: www.iss.it/documents/20126/8403839/LG-483-AIOM_Rene-2021 (accessed on 13th November 2023).

4. ESMO. Clinical Practice Guidelines–Renal Cell Carcinoma. Available from: www.esmo.org/guidelines/guidelines-by-topic/genitourinary-cancers/renal-cell-carcinoma (accessed on 13th November 2023).

5. NCCN. Clinical Practice Guidelines Kidney Cancer version 1.2024–June 21 2023. Available from: www.nccn.org/professionals/physician_gls/pdf/kidney.pdf (accessed on 13th November 2023).

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