Circular RNA hsa_circ_0001445 in plasma as a novel biomarker for osteoporosis in postmenopausal women

Author:

Xiang Shoukui1ORCID,Wu Yang1,Shi Huan1,Xue Lian2,Luo Kaiming1,Ding Yi3

Affiliation:

1. Department of Endocrinology, Third Affiliated Hospital of Soochow University, Jiangsu, Changzhou City 213003, China

2. Modern Medical Research Center, Third Affiliated Hospital of Soochow University, Jiangsu, Changzhou City 213003, China

3. Department of Geriatrics, Third Affiliated Hospital of Soochow University, Jiangsu, Changzhou City 213003, China

Abstract

Background: The present study evaluated the potential of hsa_circ_0001445 as a biomarker in plasma for postmenopausal patients with osteoporosis (OPO). Materials & methods: The expression levels of hsa_circ_0001445 in plasma were detected in healthy controls, patients with osteopenia (OPE) and patients with OPO by using quantitative reverse-transcriptase PCR. Results: The expression levels of hsa_circ_0001445 in plasma were much lower in OPO patients compared with OPE patients and healthy controls. Its expression was positively correlated with the T-score and was negatively correlated with β-isomerized C-terminal telopeptides (β-CTx). It could distinguish OPE or/and OPO patients from healthy controls. Moreover, its expression was significantly upregulated in the plasma of OPO patients after anti-osteoporotic treatment. Conclusion: Hsa_circ_0001445 in plasma may be a novel potential diagnostic biomarker for OPO.

Funder

Major Project of Changzhou Health Commission

Maternal and Child Health Research Project of Jiangsu Province

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

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