Neutrophil to lymphocyte ratio as a predictive biomarker for computed tomography scan use in mild traumatic brain injury

Author:

Alexiou George A1ORCID,Lianos Georgios D2ORCID,Tzima Aggeliki1,Sotiropoulos Athanasios1,Nasios Anastasios1,Metaxas Dimitris1,Zigouris Andreas1,RN Jolanda Zika1,Mitsis Michail2,Voulgaris Spyridon1

Affiliation:

1. Department of Neurosurgery, University Hospital of Ioannina, Ioannina, Greece

2. Department of Surgery, University Hospital of Ioannina, Ioannina, Greece

Abstract

Aim: Traumatic brain injury (TBI) is a serious health concern. We set out to investigate the role of neutrophil-to-lymphocytes ratio (NLR) at admission for predicting the need for computed tomography (CT) in mild-TBI. Materials & methods: A retrospective study of adult patients who presented with mild-TBI Results: One hundred and thirty patients met the inclusion criteria. Seventy-four patients had positive CT-findings. The mean NLR-levels at presentations were 5.6 ± 4.8. Patients with positive CT-findings had significant higher NLR-levels. Receiver operating characteristic curve analysis was conducted and the threshold of NLR-levels for detecting the cases with positive CT-findings was 2.5, with 78.1% sensitivity and 63% specificity Conclusion: To the best of our knowledge no previous study has assessed the value of NLR-levels for predicting the need for CT in mild-TBI.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

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