Silver sulfadiazine nanoethogel for burn healing: characterization and investigation of its in vivo effects

Abstract

Aim: Nanoethosomal formulation containing silver sulfadiazine (SSD) was used to reduce bacterial burden and healing time in burn injuries. Materials & methods: Ethosomal formulations were characterized for their size, ζ-potential, morphology, drug encapsulation efficiency and in vitro release kinetics of SSD. Results: The optimized nanoethosomal suspension with a size of 206.7 ± 1.18, and ζ-potential value of -67.3 ± 0.45 mV exhibited a high SSD encapsulation efficiency (92.03 ± 0.79%). Results of antimicrobial tests indicated SSD-loaded ethosome formulation led to a significant reduction of colony number. Histopathological results demonstrated a wound contraction rate of 96.83% for the group treated with SSD ethosomal gel while untreated group showed 59.41%. Conclusion: The SSD ethogels promotes the therapeutic effect of SSD for burn treatment.