Kaurenoic acid and its sodium salt derivative: antibacterial activity against Porphyromonas gingivalis and their mechanism of action-Reference-Cited by-同舟云学术

Kaurenoic acid and its sodium salt derivative: antibacterial activity against Porphyromonas gingivalis and their mechanism of action

Published:2018-11 Issue:14 Volume:13 Page:1585-1601
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Martins Carlos HG¹,Abrão Fariza¹,Moraes Thaís S¹,Oliveira Pollyanna F²,Tavares Denise C²,Magalhães Lizandra G³,Galvão Fábio C⁴,Veneziani Rodrigo CS³,Ambrósio Sérgio R³

Affiliation:

1. Research Laboratory of Applied Microbiology, University of Franca - UNIFRAN, Franca, 14404-600, São Paulo, Brazil

2. Laboratory of Mutagenesis, University of Franca - UNIFRAN, Franca, 14404-600, São Paulo, Brazil

3. Nucleus of Research in Sciences & Technology, University of Franca - UNIFRAN, 14404-600, São Paulo, Brazil

4. Department of Biological Sciences, São Paulo State University - UNESP, Araraquara, 14800-901, São Paulo, Brazil

Abstract

Aim: To evaluate the antibacterial activity of 12 kaurane-type diterpenes against a panel of bacteria that cause endodontic infection. Methods & materials: We conducted tests against bacteria in the planktonic or in the sessile mode, cytotoxic assays for the most promising compounds against human normal lung fibroblast cells, and Porphyromonas gingivalis (ATCC 33277) proteomic analysis. Results & conclusion: Kaurenoic acid and its salt exhibited satisfactory antibacterial action against the evaluated bacteria. Proteomic analysis suggested that these compounds might interfere in bacterial metabolism and virulence factor expression. Kaurane-type diterpenes are an important class of natural products and should be considered in the search for new irrigating solutions to treat endodontic infections.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2018-0140

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