Glucocorticoid pharmacogenetics in pediatric idiopathic nephrotic syndrome-Reference-Cited by-同舟云学术

Glucocorticoid pharmacogenetics in pediatric idiopathic nephrotic syndrome

Published:2015-09 Issue:14 Volume:16 Page:1631-1648
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Cuzzoni Eva¹,De Iudicibus Sara²,Franca Raffaella²,Stocco Gabriele³,Lucafò Marianna⁴,Pelin Marco³,Favretto Diego²,Pasini Andrea⁵,Montini Giovanni⁶,Decorti Giuliana³

Affiliation:

1. Graduate School in Reproduction & Developmental Sciences, University of Trieste, I-34127 Trieste, Italy

2. Institute for Maternal & Child Health IRCCS Burlo Garofolo, I-34137 Trieste, Italy

3. Department of Life Sciences, University of Trieste, I-34127 Trieste, Italy

4. Department of Medical, Surgical and Health Sciences, University of Trieste, I-34127 Trieste, Italy

5. Nephrology and Dialysis Unit, Department of Pediatrics, Azienda Ospedaliera Universitaria Sant'Orsola-Malpighi, I-40138 Bologna, Italy

6. Pediatric Nephrology and Dialysis Unit, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, I-20122 Milano, Italy

Abstract

Idiopathic nephrotic syndrome represents the most common type of primary glomerular disease in children: glucocorticoids (GCs) are the first-line therapy, even if considerable interindividual differences in thepir efficacy and side effects have been reported. Immunosuppressive and anti-inflammatory effects of these drugs are mainly due to the GC-mediated transcription regulation of pro- and anti-inflammatory genes. This mechanism of action is the result of a complex multistep pathway that involves the glucocorticoid receptor and several other proteins, encoded by polymorphic genes. Aim of this review is to highlight the current knowledge on genetic variants that could affect GC response, particularly focusing on children with idiopathic nephrotic syndrome.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pgs.15.101

Reference154 articles.

1. Nephrotic syndrome in childhood

2. Management of Childhood Onset Nephrotic Syndrome

3. Genetics of steroid-resistant nephrotic syndrome: a review of mutation spectrum and suggested approach for genetic testing

4. Long-term outcome of idiopathic steroid-resistant nephrotic syndrome: a multicenter study

5. Pathophysiology of focal segmental glomerulosclerosis

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Association of the MDR1 Variants (rs2032582 and rs2032583) with Steroid Response in Iraqi Children with Idiopathic Nephrotic Syndrome;Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 );2024-06-13

2. Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis;Nature Communications;2021-03-23

3. Optimizing the corticosteroid dose in steroid-sensitive nephrotic syndrome;Pediatric Nephrology;2021-02-20

4. Steroid-resistant Nephrotic Syndrome in Children: A Mini-review on Genetic Mechanisms, Predictive Biomarkers and Pharmacotherapy Strategies;Current Pharmaceutical Design;2021-02-04

5. Glucocorticoid receptors and their upstream epigenetic regulators in adults with steroid‐resistant nephrotic syndrome;BioFactors;2020-10-08