The role of filgotinib in ulcerative colitis and Crohn’s disease-Reference-Cited by-同舟云学术

The role of filgotinib in ulcerative colitis and Crohn’s disease

Published:2024-02 Issue:2 Volume:16 Page:59-74
ISSN:1750-743X
Container-title:Immunotherapy
language:en
Short-container-title:Immunotherapy

Author:

Fanizza Jacopo¹,D’Amico Ferdinando¹²,Lauri Gaetano¹,Martinez-Dominguez Samuel J³,Allocca Mariangela¹,Furfaro Federica¹,Zilli Alessandra¹,Fiorino Gionata¹,Parigi Tommaso Lorenzo¹,Radice Simona¹,Peyrin-Biroulet Laurent⁴⁵,Danese Silvio¹^ORCID

Affiliation:

1. Department of Gastroenterology & Endoscopy, IRCCS San Raffaele Hospital & Vita-Salute San Raffaele University, Milan, Italy

2. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy

3. Department of Gastroenterology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain; Aragón Health Research Institute, Zaragoza, Spain; School of Medicine, University of Zaragoza, Spain

4. University of Lorraine, Inserm, NGERE, F-54000 Nancy, France

5. Department of Gastroenterology, Nancy University Hospital, F-54500 Vandœuvre-lès-Nancy, France

Abstract

Filgotinib is an oral small molecule that selectively inhibits JAK1. It is already approved for the treatment of moderately to severely active ulcerative colitis (UC). Ongoing studies are evaluating the efficacy and safety of filgotinib in Crohn’s disease (CD). The purpose of this review is to summarize the available data regarding filgotinib in the management of UC and CD. We used Pubmed, Embase and clinicaltrials.gov websites to search all available data and currently ongoing studies regarding the efficacy and safety of filgotinib in inflammatory bowel diseases. Filgotinib is an effective and safe drug for the management of biologic-naive and biologic-experienced patients with moderate-to-severe UC. The same efficacy results have not been achieved in CD.

Publisher

Future Medicine Ltd

Subject

Oncology,Immunology,Immunology and Allergy

Link

https://www.futuremedicine.com/doi/pdf/10.2217/imt-2023-0116

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