Epidemiology and survival outcomes in stages II and III cutaneous melanoma: a systematic review

Author:

Miller Rachael1,Walker Sophie1,Shui Irene2,Brandtmüller Agnes3,Cadwell Kevin1,Scherrer Emilie2

Affiliation:

1. PHMR Ltd, Berkeley Works, Berkley Grove, Camden Town, London, UK

2. Merck & Co., Inc., Kenilworth, NJ 07033, USA

3. MSD: Pharma Hungary Ltd, Budapest, 1095, Hungary

Abstract

Aim: Management of cutaneous melanoma (CM) is continually evolving with adjuvant treatment of earlier stage disease. The aim of this review was to identify published epidemiological data for stages II–III CM. Materials & methods: Systematic searches of Medline and Embase were conducted to identify literature reporting country/region-specific incidence, prevalence, survival or mortality outcomes in stage II and/or III CM. Screening was carried out by two independent reviewers. Results & conclusion: Of 41 publications, 14 described incidence outcomes (incidence rates per stage were only reported for US and Swedish studies), 33 reported survival or mortality outcomes and none reported prevalence data. This review summarizes relevant data from published literature and highlights an overall paucity of epidemiological data in stages II and III CM.

Publisher

Future Medicine Ltd

Subject

Dermatology,Oncology

Reference58 articles.

1. Epidemiology of Melanoma

2. International Agency for Research on Cancer (IARC), WHO. Cancer incidence in five continents, CI5plus: IARC CancerBase No. 9 (2018). http://ci5.iarc.fr/CI5plus/Default.aspx

3. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

4. Metastatic Behavior in Melanoma: Timing, Pattern, Survival, and Influencing Factors

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