Decreased level of peripheral CD8+CD28+ T cells is associated with lymph node metastasis in patients with breast cancer-Reference-Cited by-同舟云学术

Decreased level of peripheral CD8+CD28+ T cells is associated with lymph node metastasis in patients with breast cancer

Published:2020-11 Issue:32 Volume:16 Page:2611-2617
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Li Yalun¹,Qian Tianyi²³,Zhao Hengqiang⁴,Zhang Zhen³⁴,Ming Yue⁵,Qiao Guangdong¹,Liu Jiaqi²⁶⁷^ORCID

Affiliation:

1. Department of Breast Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, PR China

2. Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, PR China

3. Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, PR China

4. Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, PR China

5. PET-CT Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, PR China

6. Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Beijing 100730, PR China

7. Institute of Biomedical Big Data, Wenzhou Medical University, Wenzhou 325027, PR China

Abstract

Background: Lymph node metastasis (LNM) is an independent risk factor for prognosis in patients with early breast cancer (EBC). Here we explored whether peripheral lymphocyte subtypes could be used as surrogate markers for LNM in patients with EBC. Materials & methods: The lymphocyte subpopulations in peripheral blood were measured in 152 EBC patients and 43 patients with benign breast tumors. Results: The cytotoxic T cell count was significantly lower in patients with EBC than in patients with benign tumors (244.17 ± 105.83 vs 289.97 ± 121.72; p = 0.02), especially in patients with LNM (218.36 ± 86.21; p = 0.04). Conclusion: A decreased level of peripheral CD8+CD28+ T lymphocytes is associated with LNM in patients with EBC and could be used as a potential therapeutic target for breast cancer.

Funder

Science and Technology Innovation Development Plan of Yantai City

National Natural Science Foundation of China

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2020-0614

Reference26 articles.

1. Cancer statistics, 2018

2. Breast cancer prevention based on gene-environment interaction

3. Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases

4. Tumor-educated B cells selectively promote breast cancer lymph node metastasis by HSPA4-targeting IgG

5. Hallmarks of Cancer: The Next Generation

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