Association between IL-27 gene polymorphisms and risk of papillary thyroid carcinoma-Reference-Cited by-同舟云学术

Association between IL-27 gene polymorphisms and risk of papillary thyroid carcinoma

Published:2017-02 Issue:2 Volume:11 Page:141-149
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Nie Xinwen¹,Yuan Fang¹,Chen Peng²,Pu Yan²,Zhu Jingqiang³,Wang Yichao³,Xiao Xue⁴,Che Guanglu¹,Gao Linbo⁵,Zhang Lin¹⁵

Affiliation:

1. Department of Immunology, West China School of Preclinical & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China

2. Department of Forensic Biology, West China School of Preclinical & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China

3. Department of Thyroid & Breast Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China

4. Department of Obstetrics & Gynaecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China

5. Laboratory of Molecular & Translational Medicine, West China Institute of Women & Children's Health, Key Laboratory of Birth Defects & Related Diseases of Women & Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China

Abstract

Aim: IL-27 has potent antitumor effects. We aimed to examine the contribution of single nucleotide polymorphisms in IL-27 to the risk of papillary thyroid carcinoma (PTC). Materials & methods: IL-27 rs153109 and rs17855750 were analyzed in 496 PTC patients and 629 controls, using a polymerase chain reaction–restriction fragment length polymorphism method. Results: The rs153109 AG and AG/GG genotypes were significantly associated with increased risks for PTC. Significantly increased PTC risk was also associated with rs17855750 GT and GT/GG genotypes. Combined genotypes of rs153109 AG/GG and rs17855750 GT/GG increased the risk of PTC (p < 0.05). Conclusion: These findings showed that IL-27 rs153109 and rs17855750 might be related to the tumorigenesis of PTC.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2016-0283

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