Delivering DNA origami to cells

Author:

Balakrishnan Dhanasekaran12,Wilkens Gerrit D12,Heddle Jonathan G1

Affiliation:

1. Bionanoscience & Biochemistry Laboratory, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7A, 30–387 Krakow, Poland

2. Postgraduate School of Molecular Medicine; Żwirki i Wigury 61, 02–091 Warsaw, Poland

Abstract

DNA nanotechnology research has long-held promise as a means of developing functional molecules capable of delivery to cells. Recent advances in DNA origami have begun to realize this potential but is still at the earliest stage and a number of hurdles remain. This review focuses on progress in addressing these hurdles and considers some of the challenges still outstanding. These include stability of such structures necessary to reach target cells after administration; methods of cell targeting and uptake; strategies to avoid or escape endosomes and techniques for achieving specific subcellular localization. Finally, the functionality that can be expected once DNA origami structures reach their final intracellular targets will be considered.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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