The association between expression of prolactin receptor and lymph node involvement in triple-negative breast cancer-Reference-Cited by-同舟云学术

The association between expression of prolactin receptor and lymph node involvement in triple-negative breast cancer

Published:2022-12-01 Issue:4 Volume:11 Page:
ISSN:1758-1923
Container-title:Breast Cancer Management
language:en
Short-container-title:Breast Cancer Management

Author:

Mohamadianamiri Mahdiss¹^ORCID,Ebrahimi Abdolali²,Farzaneh Farah³,Aklami Majid⁴,Momeni Mina⁵,Hajighasem Tannaz⁵,Shirazi Hossein¹,Zeinadini Mohammadreza⁶^ORCID

Affiliation:

1. Firoozgar Clinical Research & Development Center (FCRDC), Iran University of Medical Sciences (IUMS), Tehran, 15937-48711, Iran

2. Department of Pathology, Imam Hossein Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 16177-63141, Iran

3. Preventive Gynecology Research Center (PGRC), Emam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, 16177-63141, Iran

4. Department of Anesthesiology, Akbarabadi Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, 11687-43514, Iran

5. School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, 14496-14535, Iran

6. School of Medicine, Shiraz University of Medical Sciences (SUMS), Fars, 71348-14336, Iran

Abstract

Background: Triple-negative breast cancer (TNBC) is associated with a poor prognosis and requires more aggressive treatment. Aim: The study aimed to evaluate the prophetic role of the prolactin receptor (PRLR) in TNBC stratification. Materials & methods: In a retrospective study, 58 formalin-fixed paraffin-embedded tumor tissues from patients diagnosed with TNBC were examined for PRLR expression using immunohistochemistry. The potential associations between PRLR expression and tumor characteristics were assessed. Result: PRLR expression was negative in 36 (62%) patients and positive in 22 (38%) patients. The number of positive PRLR tumors was significantly higher in patients without lymph node involvement (p = 0.019). Conclusion: PRLR expression was negatively associated with lymph node invasion in TNBC.

Publisher

Future Medicine Ltd

Subject

Radiology, Nuclear Medicine and imaging,Oncology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmt-2022-0006

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