Association of <i>PON-1</i> polymorphism with susceptibility to and severity of ischemic stroke in the Chinese population-Reference-Cited by-同舟云学术

Association of PON-1 polymorphism with susceptibility to and severity of ischemic stroke in the Chinese population

Published:2022-05 Issue:3 Volume:19 Page:219-228
ISSN:1741-0541
Container-title:Personalized Medicine
language:en
Short-container-title:Personalized Medicine

Author:

Huang Jianmin¹²^ORCID,Yun Yanfang²,Chen Haiyan²,Yang Guixin²,Jiang Yongming²,Pan Yaoxin²,Yuan Shengshan²,Huang Jianjun²,Su Li²,Wu Yingning³,Lu Dong⁴,Xu Anding¹,Li Xuebin²

Affiliation:

1. Stroke Center & Neurology Division, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, 510630, China

2. Department of Neurology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Zhuang Autonomous Region, 533000, China

3. Department of Radiology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Zhuang Autonomous Region, 533000, China

4. Medical Laboratory, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Zhuang Autonomous Region, 533000, China

Abstract

Aim: The authors aimed to investigate whether polymorphisms of PON-1 were associated with the susceptibility to and severity of ischemic stroke (IS). Methods: In this study, 302 IS patients and 303 healthy controls were enrolled. Polymorphisms rs854560 and rs854572 of PON-1 were detected using SNaPshot single-nucleotide polymorphism typing technology. Results: The rs854572 polymorphism of the PON-1 gene showed a significant correlation with IS, and its GG genotype reduced the risk of IS (recessive model, p = 0.001). The GG genotype was also associated with mild stroke (p = 0.032). No association was observed between rs854560 and IS. Conclusion: PON-1 rs854572 polymorphism was related to the risk of IS and could be a biomarker to access the severity of IS.

Funder

National Natural Science Foundation of China

Publisher

Future Medicine Ltd

Subject

Pharmacology,Molecular Medicine,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pme-2021-0133

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