Association study of genetic polymorphisms in GABRD with treatment response and dose in methadone maintenance treatment

Author:

Xie Xiaohu1ORCID,Gu Jun1,Zhuang Dingding1,Chen Xiaoyu2,Zhou Yun2,Shen Wenwen1,Li Longhui1,Liu Yue1,Xu Wenjin1,Hong Qingxiao1,Chen Weisheng1,Zhou Wenhua12ORCID,Liu Huifen12ORCID

Affiliation:

1. Key Laboratory of Addiction Research of Zhejiang Province, Ningbo Kangning Hospital, Ningbo, Zhejiang, China

2. School of Medicine, Ningbo University, Ningbo, Zhejiang, China

Abstract

Aim: This study determined if gene variants in the GABA receptor delta subunit ( GABRD) are associated with treatment response and dose in methadone maintenance treatment (MMT) for heroin addiction. Materials & methods: A total of 286 MMT patients were recruited and divided into response and nonresponse groups based on retention time in therapy. A total of 177 responders were classified into low dose and high dose subgroups according to the stabilized methadone dose. Four (single nucleotide polymorphisms) SNPs (rs13303344, rs4481796, rs2376805 and rs2229110) in GABRD were genotyped using the TaqMan SNP assay. Logistic regression was used to assess the genetic effects of the SNPs in MMT. Results: No significant associations were observed between the SNPs and treatment response or dose, except the frequency of haplotype ACGC at the four SNPs significantly differed between responders and nonresponders. Conclusion: The results indicated that GABRD variants may play a small role in modulating methadone treatment response.

Funder

National Natural Science Foundation of China

Medical Health Science and Technology Projects of Zhejiang, China

Science and Technology Program of Ningbo, China

Publisher

Future Medicine Ltd

Subject

Pharmacology,Molecular Medicine,General Medicine

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