Aging, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks-Reference-Cited by-同舟云学术

Aging, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks

Published:2017-05 Issue:5 Volume:9 Page:689-700
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Armstrong Nicola J¹²,Mather Karen A¹,Thalamuthu Anbupalam¹,Wright Margaret J³⁴,Trollor Julian N¹⁵,Ames David⁶⁷,Brodaty Henry¹⁸,Schofield Peter R⁹¹⁰,Sachdev Perminder S¹¹¹,Kwok John B⁹¹⁰¹²

Affiliation:

1. Centre for Healthy Brain Aging, School of Psychiatry, UNSW Australia, Sydney, Australia

2. Department of Mathematics & Statistics, Murdoch University, Perth, Australia

3. Queensland Brain Institute, University of Queensland, Brisbane, Australia

4. Centre for Advanced Imaging, University of Queensland, Brisbane, Australia

5. Department of Developmental Disability Neuropsychiatry, UNSW Australia, Sydney, Australia

6. Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Australia

7. National Aging Research Institute, Melbourne, Australia

8. Dementia Collaborative Research Centre – Assessment & Better Care, UNSW Australia, Sydney, Australia

9. Neuroscience Research Australia, Sydney, Australia

10. School of Medical Sciences, UNSW Australia, Sydney, Australia

11. Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, Australia

12. Brain and Mind Centre - University of Sydney, Camperdown, Australia

Abstract

Aim: To examine the relationships between two epigenetic clocks, aging and exceptional longevity. Materials & methods: Participants were from three adult cohorts with blood DNA methylation data (Illumina 450 K, n = 275, 34–103 years). Epigenetic age (DNAmage) and age acceleration measures were calculated using the Hannum and Horvath epigenetic clocks. Results: Across all cohorts, DNAmage was correlated with chronological age. In the long-lived cohort (Sydney Centenarian Study; 95+, n = 23), DNAmage was lower than chronological age for both clocks. Mean Sydney Centenarian Study Hannum age acceleration was negative, while the converse was observed for the Horvath model. Conclusion: Long-lived individuals have a young epigenetic age compared with their chronological age.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2016-0179

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