Tobacco smoking-associated genome-wide DNA methylation changes in the EPIC study-Reference-Cited by-同舟云学术

Tobacco smoking-associated genome-wide DNA methylation changes in the EPIC study

Published:2016-05 Issue:5 Volume:8 Page:599-618
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Ambatipudi Srikant¹,Cuenin Cyrille¹,Hernandez-Vargas Hector¹,Ghantous Akram¹,Le Calvez-Kelm Florence¹,Kaaks Rudolf²,Barrdahl Myrto²,Boeing Heiner³,Aleksandrova Krasimira³,Trichopoulou Antonia⁴⁵,Lagiou Pagona⁴⁵,Naska Androniki⁴⁵,Palli Domenico⁶,Krogh Vittorio⁷,Polidoro Silvia⁸,Tumino Rosario⁹,Panico Salvatore¹⁰,Bueno-de-Mesquita Bas¹¹¹²¹³¹⁴,Peeters Petra HM¹⁵¹⁶,Quirós José Ramón¹⁷,Navarro Carmen¹⁸¹⁹²⁰,Ardanaz Eva¹⁹²¹²²,Dorronsoro Miren²³,Key Tim²⁴,Vineis Paolo²⁵,Murphy Neil²⁵,Riboli Elio²⁵,Romieu Isabelle¹,Herceg Zdenko¹

Affiliation:

1. International Agency for Research on Cancer (IARC), Lyon, France

2. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

3. Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany

4. Hellenic Health Foundation, Athens, Greece

5. WHO Collaborating Center for Nutrition & Health, Unit of Nutritional Epidemiology & Nutrition in Public Health, Department of Hygiene, Epidemiology & Medical Statistics, University of Athens Medical School, Athens, Greece

6. Molecular & Nutritional Epidemiology Unit, Cancer Research & Prevention Institute–ISPO, Florence, Italy

7. Epidemiology & Prevention Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy

8. Human Genetic Foundation (HuGeF), Torino, Italy

9. Cancer Registry & Histopathology Unit, ‘Civic MP Arezzo’ Hospital, ASP Ragusa, Italy

10. Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy

11. Department of Determinants of Chronic Diseases (DCD), National Institute for Public Health & the Environment (RIVM), Bilthoven, The Netherlands

12. Department of Gastroenterology & Hepatology, University Medical Centre, Utrecht, The Netherlands

13. Department of Epidemiology & Biostatistics, The School of Public Health, Imperial College London, London, UK

14. Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

15. Department of Epidemiology, Julius Center for Health Sciences & Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

16. MRC-PHE Centre for Environment & Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK

17. Public Health Directorate, Asturias, Spain

18. Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain

19. CIBER Epidemiología y Salud Pública (CIBERESP), Spain

20. Department of Health & Social Sciences, Universidad de Murcia, Spain

21. Public Health Institute of Navarra, Pamplona, Spain

22. IdiSNA, Navarra Institute for Health Research, Pamplona, Spain

23. Public Health Direction and Biodonostia–Ciberesp, Basque Regional Health Department, San Sebastian, Spain

24. Cancer Epidemiology Unit, University of Oxford, Oxford, UK

25. School of Public Health, Imperial College London, London, UK

Abstract

Aim: Epigenetic changes may occur in response to environmental stressors, and an altered epigenome pattern may represent a stable signature of environmental exposure. Materials & methods: Here, we examined the potential of DNA methylation changes in 910 prediagnostic peripheral blood samples as a marker of exposure to tobacco smoke in a large multinational cohort. Results: We identified 748 CpG sites that were differentially methylated between smokers and nonsmokers, among which we identified novel regionally clustered CpGs associated with active smoking. Importantly, we found a marked reversibility of methylation changes after smoking cessation, although specific genes remained differentially methylated up to 22 years after cessation. Conclusion: Our study has comprehensively cataloged the smoking-associated DNA methylation alterations and showed that these alterations are reversible after smoking cessation.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2016-0001

Reference58 articles.

1. WHO. Burden: mortality, morbidity and risk factors. www.who.int/nmh/publications/ncd_report_chapter1.pdf

2. Current Genetics and Epigenetics of Smoking/Tobacco-Related Cardiovascular Disease

3. Epigenetic mechanisms and cancer: An interface between the environment and the genome

4. Characterising the epigenome as a key component of the fetal exposome in evaluating in utero exposures and childhood cancer risk

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